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水稻團隊發布基于深度學習模型預測植物基因組序列變異調控效應的網絡服務
發布時間: 2021-05-31

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水稻團隊發布基于深度學習模型預測植物基因組序列變異調控效應的網絡服務

gaiyanjiuzhong,xieweibojiaoshouketizutongguoatac-seqjishuhuode5zhonghebenkezhiwuwuzhong(baohan4zhongzuowu)duogezuzhidegaozhiliangransezhikejixingshuju,bingshoujileyifabiaoninanjieshuju,congzhongjiandingleocr。liyonggegewuzhongduiyingdecankaojiyinzuxulieyijiocrxinxi,shiyongshenduxueximoxingkuangjiadeepseajinxingxunlian。tongguopinggu,gemoxingquxianxiamianji(auroc)zai0.93-0.99zhijian,biaomingsuogoujiandexiliemoxingjuyoujiaogaokeyongxing。

xieweibojiaoshouketizujiyusuohuodedeshenduxueximoxing,goujianleplantdeepsea()wangluofuwu,mianfeigongsuoyouyonghushiyong。gaiwangzhanzhuyaobaohan2xianggongneng: yishivariant effector,qimudeshiyucexuliebianyiduiyugezuzhizhongransezhikejixingdeyingxiang,yonghuketijiaovcfwenjianjinxingbianyixiaoyingyuce;yishisequence profiler,gaigongjuliyong"in silico saturated mutagenesis"wajuexuliezhongdegaoyingxiangliweidian(high-impact sites,rushunshidiaokongyuanjian)。yonghukexuanzeransetibianhaoheshurujiyinzuzuobiao、renyiyiduanhegansuanxuliehuozhebaohanyigehuoduogeransetiquduandebedwenjianjinxingfenxi。youyujisuanziyuansuoxian,muqianplantdeepseayunxu1citijiaozuiduo2000gebianyiweidianjinxingbianyixiaoyingyuce,yiji5gequduanjinxingdiaokongyuanjianfenxi。

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